Anne with an E

= Plot =

Main character

 * Amybeth McNulty as Anne Shirley (later called Anne Shirley-Cuthbert)
 * Geraldine James as Marilla Cuthbert
 * Dalila Bela as Diana Barry
 * Lucas Jade Zumann as Gilbert Blythe
 * Aymeric Jett Montaz as Jerry Baynard
 * R. H. Thomson as Matthew Cuthbert
 * Corrine Koslo as Rachel Lynde (seasons 2–3; recurring season 1)
 * Dalmar Abuzeid as Sebastian "Bash" Lacroix (seasons 2–3)
 * Cory Grüter-Andrew as Cole Mackenzie (seasons 2–3)
 * Joanna Douglas as Miss Muriel Stacy (season 3; recurring season 2)
 * Ashleigh Stewart as Winifred "Winnie" Rose (season 3)

Recurring and guest

 * Jonathan Holmes as Mr. William Barry
 * Helen Johns as Mrs. Eliza Barry
 * Ryan Kiera Armstrong as Minnie May Barry
 * Deborah Grover as Josephine Barry
 * Wayne Best as John Blythe
 * Phillip Williams as Thomas Lynde
 * David Ingram as Mr. Harmon Andrews
 * Janet Porter as Mrs. Andrews
 * Christian Martyn as Billy Andrews
 * Lia Pappas-Kemps as Jane Andrews
 * Ella Jonas Farlinger as Prissy Andrews
 * Jim Annan as Mr. Gillis
 * Fiona Byrne as Mrs. Gillis
 * Kyla Matthews as Ruby Gillis
 * Jacob Ursomarzo as Moody Spurgeon
 * Stephen Tracey as Mr. Phillips
 * Miranda McKeon as Josie Pye
 * Glenna Walters as Tillie Boulter
 * Katelyn Wells as Mary Joe
 * Jacob Horsley as Charlie Sloane
 * Taras Lavren as Nate
 * Shane Carty as Mr. Dunlop
 * Cara Ricketts as Mary LaCroix
 * Araya Mengesha as Elijah Hanford
 * Nicky Lawrence as Jocelyn
 * Lisa Codrington as Constance
 * Melanie Nicholls-King as Hazel Lacroix
 * Kiawentiio Tarbell as Ka'kwet
 * Brandon Oakes as Aluk
 * Dana Jeffrey as Oqwatnuk
 * Ines Feghouli as Sandy Baynard
 * Trenna Keating as Mrs. Pye